Reaction: Methyldopa to 1 product

Reaction
Methyldopa
DB00968
Alpha-methyldopamine
DBMET00785
Reaction type
decarboxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. BUHS RP, BECK JL, SPETH OC, SMITH JL, TRENNER NR, CANNON PJ, LARAGH JH: THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS. J Pharmacol Exp Ther. 1964 Feb;143:205-14. [Article]
  2. Au WY, Dring LG, Grahame-Smith DG, Isaac P, Williams RT: The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects. Biochem J. 1972 Aug;129(1):1-10. doi: 10.1042/bj1290001. [Article]
  3. Campbell NR, Sundaram RS, Werness PG, Van Loon J, Weinshilboum RM: Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15. doi: 10.1038/clpt.1985.45. [Article]
  4. Robertson D, Tung CS, Goldberg MR, Hollister AS, Gerkens JF, Oates JA: Antihypertensive metabolites of alpha-methyldopa. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II45-50. doi: 10.1161/01.hyp.6.5_pt_2.ii45. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Aromatic-L-amino-acid decarboxylaseNot AvailableNot Availableconfirmed