Reaction: Doxorubicin to 1 product

Reaction
Reaction type
Deglycosydation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
  2. Mordente A, Meucci E, Silvestrini A, Martorana GE, Giardina B: New developments in anthracycline-induced cardiotoxicity. Curr Med Chem. 2009;16(13):1656-72. [Article]
  3. Licata S, Saponiero A, Mordente A, Minotti G: Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction. Chem Res Toxicol. 2000 May;13(5):414-20. doi: 10.1021/tx000013q. [Article]
  4. Lin SR, Lin CS, Chen CC, Tseng FJ, Wu TJ, Weng L, Weng CF: Doxorubicin metabolism moderately attributes to putative toxicity in prodigiosin/doxorubicin synergism in vitro cells. Mol Cell Biochem. 2020 Dec;475(1-2):119-126. doi: 10.1007/s11010-020-03864-x. Epub 2020 Aug 4. [Article]
  5. Niitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M, Honma Y: Anticancer derivative of butyric acid (Pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol. 2000 Jul;58(1):27-36. [Article]
  6. Gutierrez PL, Gee MV, Bachur NR: Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity. Arch Biochem Biophys. 1983 May;223(1):68-75. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
NADPH--cytochrome P450 reductaseNot AvailableNot Availableconfirmed
Xanthine dehydrogenase/oxidaseNot AvailableNot Availableconfirmed
NAD(P)H dehydrogenase [quinone] 1Not AvailableNot Availableconfirmed