Reaction: Ketotifen to 1 product

Reaction
Ketotifen
DB00920
Ketotifen-N-glucuronide
DBMET00894
Reaction type
N-glucuronidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Hawes EM: N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group. Drug Metab Dispos. 1998 Sep;26(9):830-7. [Article]
  2. Kato Y, Izukawa T, Oda S, Fukami T, Finel M, Yokoi T, Nakajima M: Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97. doi: 10.1124/dmd.113.051565. Epub 2013 Apr 23. [Article]
  3. Health Canada Product Monograph: Zaditen (ketotifen fumarate) for oral administration [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-3Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-4Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 2B10Not AvailableNot Availableconfirmed