Reaction: Mycophenolic acid to 1 product

Reaction
Mycophenolic acid
DB01024
Mycophenolic acid-7-O-glucuronide
DBMET00917
Reaction type
O-glucuronidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
  2. Bernard O, Guillemette C: The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants. Drug Metab Dispos. 2004 Aug;32(8):775-8. doi: 10.1124/dmd.32.8.775. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-8Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-10Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-9Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-7Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableconfirmed