Clopidogrel bisulfateProduct ingredient for Clopidogrel

Name
Clopidogrel bisulfate
Drug Entry
Clopidogrel

Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,9

It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.8

Clopidogrel was granted FDA approval on 17 November 1997.9

Accession Number
DBSALT000029
Structure
Thumb
Synonyms
Clopidogrel hemisulfate / Clopidogrel hydrogen sulfate
External IDs
SR 25990C / SR-25990C
UNII
08I79HTP27
CAS Number
120202-66-6
Weight
Average: 419.9
Monoisotopic: 419.0264064
Chemical Formula
C16H18ClNO6S2
InChI Key
FDEODCTUSIWGLK-RSAXXLAASA-N
InChI
InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m0./s1
IUPAC Name
methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate; sulfuric acid
SMILES
OS(O)(=O)=O.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
External Links
KEGG Drug
D00769
PubChem Compound
115366
ChemSpider
103200
ChEBI
3759
ChEMBL
CHEMBL1083385
Wikipedia
Clopidogrel
Predicted Properties
PropertyValueSource
Water Solubility0.0118 mg/mLALOGPS
logP3.84ALOGPS
logP4.03ChemAxon
logS-4.4ALOGPS
pKa (Strongest Basic)5.14ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity84.93 m3·mol-1ChemAxon
Polarizability32.77 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon