Pazopanib hydrochlorideProduct ingredient for Pazopanib
- Name
- Pazopanib hydrochloride
- Drug Entry
- Pazopanib
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
- Accession Number
- DBSALT000135
- Structure
Structure for Pazopanib hydrochloride (DBSALT000135)
- Synonyms
- Pazopanib HCl
- External IDs
- GW-786034B / GW786034B
- UNII
- 33Y9ANM545
- CAS Number
- 635702-64-6
- Weight
- Average: 473.979
Monoisotopic: 473.140071444 - Chemical Formula
- C21H24ClN7O2S
- InChI Key
- MQHIQUBXFFAOMK-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
- IUPAC Name
- 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide hydrochloride
- SMILES
- Cl.CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=NC(NC2=CC(=C(C)C=C2)S(N)(=O)=O)=NC=C1
- External Links
- PubChem Compound
- 11525740
- ChemSpider
- 9700526
- ChEBI
- 71217
- ChEMBL
- CHEMBL1201733
- Wikipedia
- Pazopanib
- Predicted Properties
Property Value Source Water Solubility 0.0433 mg/mL ALOGPS logP 3.59 ALOGPS logP 3.55 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 10.41 Chemaxon pKa (Strongest Basic) 4.36 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 119.03 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 132.18 m3·mol-1 Chemaxon Polarizability 46.92 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon