Succinylcholine chlorideProduct ingredient for Succinylcholine
- Name
- Succinylcholine chloride
- Drug Entry
- Succinylcholine
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups.2 It has been widely used for over 50 years,1 most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.9
- Accession Number
- DBSALT000206
- Structure
Structure for Succinylcholine chloride (DBSALT000206)
- Synonyms
- Choline chloride succinate (2:1) / Cloruro de suxametonio / Succinilcolina cloruro / Succinylcholine chloride / Suxamethonii chloridum / Suxamethonium chloride
- UNII
- I9L0DDD30I
- CAS Number
- 71-27-2
- Weight
- Average: 361.305
Monoisotopic: 360.158262872 - Chemical Formula
- C14H30Cl2N2O4
- InChI Key
- YOEWQQVKRJEPAE-UHFFFAOYSA-L
- InChI
- InChI=1S/C14H30N2O4.2ClH/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
- IUPAC Name
- trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium dichloride
- SMILES
- [Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.00122 mg/mL ALOGPS logP -3.6 ALOGPS logP -8.4 Chemaxon logS -5.5 ALOGPS pKa (Strongest Basic) -6.8 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 52.6 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 100.94 m3·mol-1 Chemaxon Polarizability 33.46 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon