Sufentanil citrateProduct ingredient for Sufentanil
- Name
- Sufentanil citrate
- Drug Entry
- Sufentanil
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.
Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments 10. Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately 11.
The sublingual form, manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx), was approved on November 2, 2018 10. This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural administration 10, 4.
- Accession Number
- DBSALT000275
- Structure
- Synonyms
- Not Available
- UNII
- S9ZFX8403R
- CAS Number
- 60561-17-3
- Weight
- Average: 578.674
Monoisotopic: 578.229801514 - Chemical Formula
- C28H38N2O9S
- InChI Key
- OJCZPLDERGDQRJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H30N2O2S.C6H8O7/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-10,17H,3,11-16,18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
- IUPAC Name
- 2-hydroxypropane-1,2,3-tricarboxylic acid; N-[4-(methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropanamide
- SMILES
- OC(=O)CC(O)(CC(O)=O)C(O)=O.CCC(=O)N(C1=CC=CC=C1)C1(COC)CCN(CCC2=CC=CS2)CC1
- External Links
- PubChem Compound
- 65494
- ChemSpider
- 58942
- ChEBI
- 9317
- ChEMBL
- CHEMBL1201163
- Wikipedia
- Sufentanil
- Predicted Properties
Property Value Source Water Solubility 0.012 mg/mL ALOGPS logP 3.4 ALOGPS logP 3.61 Chemaxon logS -4.5 ALOGPS pKa (Strongest Basic) 8.86 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 32.78 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 111.42 m3·mol-1 Chemaxon Polarizability 44.16 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon