Fosphenytoin sodiumProduct ingredient for Fosphenytoin
- Name
- Fosphenytoin sodium
- Drug Entry
- Fosphenytoin
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
- Accession Number
- DBSALT000296
- Structure
Structure for Fosphenytoin sodium (DBSALT000296)
- Synonyms
- Not Available
- UNII
- 7VLR55452Z
- CAS Number
- 92134-98-0
- Weight
- Average: 406.2375
Monoisotopic: 406.03066202 - Chemical Formula
- C16H13N2Na2O6P
- InChI Key
- GQPXYJNXTAFDLT-UHFFFAOYSA-L
- InChI
- InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
- IUPAC Name
- disodium 1-[(hydrogen phosphonatooxy)methyl]-5-oxo-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-olate
- SMILES
- [Na+].[Na+].OP([O-])(=O)OCN1C([O-])=NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- PubChem Compound
- 56338
- ChemSpider
- 50838
- ChEBI
- 183044
- ChEMBL
- CHEMBL919
- Wikipedia
- Fosphenytoin
- Predicted Properties
Property Value Source Water Solubility 1.49 mg/mL ALOGPS logP 1.8 ALOGPS logP 2.49 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 1.44 Chemaxon pKa (Strongest Basic) -0.61 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 125.32 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 97 m3·mol-1 Chemaxon Polarizability 32.68 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon