Liothyronine sodiumProduct ingredient for Liothyronine
- Name
- Liothyronine sodium
- Drug Entry
- Liothyronine
Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.3 The exogenous liothyronine product was developed by King Pharmaceuticals and FDA approved in 1956.8
- Accession Number
- DBSALT000321
- Structure
Structure for Liothyronine sodium (DBSALT000321)
- Synonyms
- Not Available
- UNII
- GCA9VV7D2N
- CAS Number
- 55-06-1
- Weight
- Average: 672.9553
Monoisotopic: 672.77198278 - Chemical Formula
- C15H11I3NNaO4
- InChI Key
- SBXXSUDPJJJJLC-UHFFFAOYSA-M
- InChI
- InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1
- IUPAC Name
- sodium 4-{4-[(2S)-2-amino-2-carboxyethyl]-2,6-diiodophenoxy}-2-iodobenzen-1-olate
- SMILES
- [Na+].[H][C@](N)(CC1=CC(I)=C(OC2=CC(I)=C([O-])C=C2)C(I)=C1)C(O)=O
- External Links
- PubChem Compound
- 23666110
- ChemSpider
- 4642561
- ChEBI
- 6484
- ChEMBL
- CHEMBL1360294
- Wikipedia
- Thyroid_hormones
- Predicted Properties
Property Value Source Water Solubility 0.00721 mg/mL ALOGPS logP 1.04 ALOGPS logP 2.8 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 0.3 Chemaxon pKa (Strongest Basic) 9.48 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.61 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 123.98 m3·mol-1 Chemaxon Polarizability 43.67 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon