Prazosin hydrochlorideProduct ingredient for Prazosin

Show full entry for Prazosin
Name
Prazosin hydrochloride
Drug Entry
Prazosin

Prazosin is a drug used to treat hypertension. Prazosin is marketed by Pfizer and was initially approved by the FDA in 1988.16 It belongs to the class of drugs known as alpha-1 antagonists.

Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.4,5,6

See full entry for Prazosin
Accession Number
DBSALT000329
Structure
Similar Structures
Synonyms
Prazosin HCl
UNII
X0Z7454B90
CAS Number
19237-84-4
Weight
Average: 419.862
Monoisotopic: 419.136031924
Chemical Formula
C19H22ClN5O4
InChI Key
WFXFYZULCQKPIP-UHFFFAOYSA-N
InChI
InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
IUPAC Name
2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine hydrochloride
SMILES
Cl.COC1=C(OC)C=C2C(=N)NC(=NC2=C1)N1CCN(CC1)C(=O)C1=CC=CO1
PubChem Compound
68546
ChemSpider
61820
ChEBI
8365
ChEMBL
CHEMBL1558
Wikipedia
Prazosin
Predicted Properties
PropertyValueSource
Water Solubility0.456 mg/mLALOGPS
logP1.21ALOGPS
logP0.52Chemaxon
logS-2.9ALOGPS
pKa (Strongest Acidic)11.09Chemaxon
pKa (Strongest Basic)13.32Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area103.39 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity115.04 m3·mol-1Chemaxon
Polarizability40.26 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon