Ketamine hydrochlorideProduct ingredient for Ketamine
- Name
- Ketamine hydrochloride
- Drug Entry
- Ketamine
Ketamine is an NMDA receptor antagonist with a potent anesthetic effect.6 It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic effects. It was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients undergoing minor surgeries but mainly for veterinary purposes.14
- Accession Number
- DBSALT000396
- Structure
Structure for Ketamine hydrochloride (DBSALT000396)
- Synonyms
- (±)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride / (±)-ketamine hydrochloride / Ketamine HCl / Ketamine hydrochloride
- External IDs
- CI-581 / CL 369 / CL-369 / CN-52372-2 / DEA No. 7285 / PMI-150
- UNII
- O18YUO0I83
- CAS Number
- 1867-66-9
- Weight
- Average: 274.186
Monoisotopic: 273.068719585 - Chemical Formula
- C13H17Cl2NO
- InChI Key
- VCMGMSHEPQENPE-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H
- IUPAC Name
- 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride
- SMILES
- Cl.CNC1(CCCCC1=O)C1=CC=CC=C1Cl
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0464 mg/mL ALOGPS logP 2.69 ALOGPS logP 3.35 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 19.77 Chemaxon pKa (Strongest Basic) 7.16 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 29.1 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 65.55 m3·mol-1 Chemaxon Polarizability 24.97 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon