Fludarabine phosphateProduct ingredient for Fludarabine
- Name
- Fludarabine phosphate
- Drug Entry
- Fludarabine
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
- Accession Number
- DBSALT000425
- Structure
- Synonyms
- 2-Fluoro-ARA AMP / 2-Fluoroadenine arabinoside 5'-monophosphate / 2F-ara-AMP / 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate / 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) / 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate / FAMP / Fludarabine 5'-monophosphate / Fludarabine monophosphate / Fludarabine phosphate
- UNII
- 1X9VK9O1SC
- CAS Number
- 75607-67-9
- Weight
- Average: 365.2117
Monoisotopic: 365.053662512 - Chemical Formula
- C10H13FN5O7P
- InChI Key
- GIUYCYHIANZCFB-FJFJXFQQSA-N
- InChI
- InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
- IUPAC Name
- {[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
- SMILES
- NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]3O)C2=NC(F)=N1
- External Links
- Human Metabolome Database
- HMDB0015206
- KEGG Drug
- D01907
- PubChem Compound
- 30751
- ChemSpider
- 28532
- BindingDB
- 50248004
- ChEBI
- 63599
- ChEMBL
- CHEMBL1096882
- ZINC
- ZINC000003927870
- PharmGKB
- PA449655
- Wikipedia
- Fludarabine
- Predicted Properties
Property Value Source Water Solubility 2.97 mg/mL ALOGPS logP -2.5 ALOGPS logP -2 Chemaxon logS -2.1 ALOGPS pKa (Strongest Acidic) 1.35 Chemaxon pKa (Strongest Basic) 0.63 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 10 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 186.07 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 74.93 m3·mol-1 Chemaxon Polarizability 30.03 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon