Maprotiline hydrochlorideProduct ingredient for Maprotiline
- Name
- Maprotiline hydrochloride
- Drug Entry
- Maprotiline
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
- Accession Number
- DBSALT000482
- Structure
Structure for Maprotiline hydrochloride (DBSALT000482)
- Synonyms
- Maprotiline HCl / Maprotiline hydrochloride
- External IDs
- BA 34276 / Ciba 34276 Ba
- UNII
- 7C8J54PVFI
- CAS Number
- 10347-81-6
- Weight
- Average: 313.864
Monoisotopic: 313.15972748 - Chemical Formula
- C20H24ClN
- InChI Key
- NZDMFGKECODQRY-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
- IUPAC Name
- methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaen-1-yl}propyl)amine hydrochloride
- SMILES
- Cl.CNCCCC12CCC(C3=CC=CC=C13)C1=C2C=CC=C1
- External Links
- KEGG Drug
- D00818
- PubChem Compound
- 71478
- ChemSpider
- 64557
- ChEBI
- 6691
- ChEMBL
- CHEMBL1237135
- Wikipedia
- Maprotiline
- Predicted Properties
Property Value Source logP 4.37 Chemaxon pKa (Strongest Basic) 10.54 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 99.3 m3·mol-1 Chemaxon Polarizability 33.57 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon