Cefotaxime sodiumProduct ingredient for Cefotaxime
- Name
- Cefotaxime sodium
- Drug Entry
- Cefotaxime
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
- Accession Number
- DBSALT000547
- Structure
Structure for Cefotaxime sodium (DBSALT000547)
- Synonyms
- Not Available
- UNII
- 258J72S7TZ
- CAS Number
- 64485-93-4
- Weight
- Average: 477.447
Monoisotopic: 477.038883946 - Chemical Formula
- C16H16N5NaO7S2
- InChI Key
- AZZMGZXNTDTSME-REMKHYEUSA-M
- InChI
- InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;
- IUPAC Name
- sodium (2Z)-N-[(6R,7S)-3-[(acetyloxy)methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethanimidate
- SMILES
- [Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@]2([H])N=C([O-])C(=N/OC)\C1=CSC(=N)N1)C(O)=O
- External Links
- PubChem Compound
- 23698758
- ChemSpider
- 10444362
- Wikipedia
- Cefotaxime
- Predicted Properties
Property Value Source Water Solubility 0.147 mg/mL ALOGPS logP 0.85 ALOGPS logP -1.8 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 2.74 Chemaxon pKa (Strongest Basic) 9.84 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 10 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 176.8 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 128.97 m3·mol-1 Chemaxon Polarizability 42.96 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon