Nortriptyline hydrochlorideProduct ingredient for Nortriptyline
- Name
- Nortriptyline hydrochloride
- Drug Entry
- Nortriptyline
Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA).18 It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.19
- Accession Number
- DBSALT000641
- Structure
Structure for Nortriptyline hydrochloride (DBSALT000641)
- Synonyms
- Nortriptyline HCl
- UNII
- 00FN6IH15D
- CAS Number
- 894-71-3
- Weight
- Average: 299.838
Monoisotopic: 299.144077416 - Chemical Formula
- C19H22ClN
- InChI Key
- SHAYBENGXDALFF-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
- IUPAC Name
- methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine hydrochloride
- SMILES
- Cl.CNCCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
- External Links
- PubChem Compound
- 13468
- ChemSpider
- 12891
- ChEBI
- 7641
- ChEMBL
- CHEMBL1201156
- Wikipedia
- Nortriptyline
- Predicted Properties
Property Value Source Water Solubility 0.000874 mg/mL ALOGPS logP 4.65 ALOGPS logP 4.43 Chemaxon logS -5.5 ALOGPS pKa (Strongest Basic) 10.47 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 96.21 m3·mol-1 Chemaxon Polarizability 31.54 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon