Mecamylamine hydrochlorideProduct ingredient for Mecamylamine

Show full entry for Mecamylamine
Name
Mecamylamine hydrochloride
Drug Entry
Mecamylamine

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

See full entry for Mecamylamine
Accession Number
DBSALT000652
Structure
Similar Structures
Synonyms
Mecamylamine HCl
UNII
4956DJR58O
CAS Number
826-39-1
Weight
Average: 203.752
Monoisotopic: 203.144077416
Chemical Formula
C11H22ClN
InChI Key
PKVZBNCYEICAQP-UHFFFAOYSA-N
InChI
InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
IUPAC Name
N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
SMILES
Cl.CNC1(C)C2CCC(C2)C1(C)C
PubChem Compound
13221
ChemSpider
12666
ChEBI
6707
ChEMBL
CHEMBL1237082
Wikipedia
Mecamylamine
Predicted Properties
PropertyValueSource
Water Solubility0.124 mg/mLALOGPS
logP3.13ALOGPS
logP2.37Chemaxon
logS-3.1ALOGPS
pKa (Strongest Basic)10.88Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area12.03 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity51.83 m3·mol-1Chemaxon
Polarizability20.74 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon