Naftifine HydrochlorideProduct ingredient for Naftifine
- Name
- Naftifine Hydrochloride
- Drug Entry
- Naftifine
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
- Accession Number
- DBSALT000677
- Structure
Structure for Naftifine Hydrochloride (DBSALT000677)
- Synonyms
- Naftifine HCl
- UNII
- 25UR9N9041
- CAS Number
- 65473-14-5
- Weight
- Average: 323.859
Monoisotopic: 323.144077416 - Chemical Formula
- C21H22ClN
- InChI Key
- OLUNPKFOFGZHRT-YGCVIUNWSA-N
- InChI
- InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
- IUPAC Name
- methyl[(naphthalen-1-yl)methyl][(2E)-3-phenylprop-2-en-1-yl]amine hydrochloride
- SMILES
- Cl.[H]\C(CN(C)CC1=CC=CC2=CC=CC=C12)=C(\[H])C1=CC=CC=C1
- External Links
- KEGG Compound
- C08072
- PubChem Compound
- 5281098
- ChemSpider
- 4444547
- ChEBI
- 7452
- ChEMBL
- CHEMBL1200493
- Predicted Properties
Property Value Source Water Solubility 0.000229 mg/mL ALOGPS logP 4.96 ALOGPS logP 5.24 Chemaxon logS -6.1 ALOGPS pKa (Strongest Basic) 8.99 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 3.24 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 95.98 m3·mol-1 Chemaxon Polarizability 34.38 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon