Olopatadine hydrochlorideProduct ingredient for Olopatadine
- Name
- Olopatadine hydrochloride
- Drug Entry
- Olopatadine
Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions. It is a structural analog of doxepin, which has a minimal anti-allergic activity.10 Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator that causes inflammatory and allergic reactions. An ophthalmic solution of olopatadine was approved by the FDA and European Union for the treatment of seasonal and perennial allergic conjunctivitis in 1996 and 2002, respectively.2 In comparison to other anti-allergenic ophthalmic medications, olopatadine displays a good comfort and tolerability profile since it does not cause perturbation of cell membranes.6 Olopatadine is used for the symptomatic treatment of ocular itching associated with allergic conjunctivitis in ophthalmic formulations and seasonal allergic rhinitis in intranasal formulations. It is currently marketed under several brand names, including Pazeo, Patanase, and Opatanol.
- Accession Number
- DBSALT000685
- Structure
Structure for Olopatadine hydrochloride (DBSALT000685)
- Synonyms
- Olopatadine HCl
- UNII
- 2XG66W44KF
- CAS Number
- 140462-76-6
- Weight
- Average: 373.873
Monoisotopic: 373.144471346 - Chemical Formula
- C21H24ClNO3
- InChI Key
- HVRLZEKDTUEKQH-NOILCQHBSA-N
- InChI
- InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
- IUPAC Name
- 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl]acetic acid hydrochloride
- SMILES
- Cl.[H]\C(CCN(C)C)=C1/C2=CC=CC=C2COC2=C1C=C(CC(O)=O)C=C2
- External Links
- PubChem Compound
- 5282402
- ChemSpider
- 4445557
- ChEBI
- 31933
- ChEMBL
- CHEMBL1719
- Wikipedia
- Olopatadine
- Predicted Properties
Property Value Source Water Solubility 0.0313 mg/mL ALOGPS logP 3.99 ALOGPS logP 0.75 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 3.78 Chemaxon pKa (Strongest Basic) 9.76 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 49.77 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 109.55 m3·mol-1 Chemaxon Polarizability 37.48 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon