Prednisolone sodium phosphateProduct ingredient for Prednisolone phosphate

Show full entry for Prednisolone phosphate
Name
Prednisolone sodium phosphate
Drug Entry
Prednisolone phosphate

Prednisolone phosphate is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.2

Prednisolone phosphate was granted FDA Approval on 19 December 1973.8

See full entry for Prednisolone phosphate
Accession Number
DBSALT000785
Structure
Similar Structures
Synonyms
Prednisolone (as sodium phosphate) / Prednisolone 21-disodium phosphate
UNII
IV021NXA9J
CAS Number
125-02-0
Weight
Average: 484.3876
Monoisotopic: 484.123893702
Chemical Formula
C21H27Na2O8P
InChI Key
VJZLQIPZNBPASX-OJJGEMKLSA-L
InChI
InChI=1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1
IUPAC Name
disodium (1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-1-[2-(phosphonooxy)acetyl]-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
SMILES
[Na+].[Na+].[H][C@@]12CC[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
KEGG Compound
C07369
PubChem Compound
5755
ChemSpider
390145
ChEBI
8379
ChEMBL
CHEMBL1201014
Wikipedia
Prednisolone_sodium_phosphate
Predicted Properties
PropertyValueSource
Water Solubility1.58 mg/mLALOGPS
logP1.87ALOGPS
logP1.15Chemaxon
logS-2.5ALOGPS
pKa (Strongest Acidic)1.18Chemaxon
pKa (Strongest Basic)-2.9Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area147.02 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity107.12 m3·mol-1Chemaxon
Polarizability42.92 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon