Ethopropazine hydrochlorideProduct ingredient for Profenamine
- Name
- Ethopropazine hydrochloride
- Drug Entry
- Profenamine
Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada.1 In the US, the marketing of profenamine has been discontinued.2
- Accession Number
- DBSALT000813
- Structure
- Synonyms
- 10-(2-(diethylamino)propyl)phenothiazine monohydrochloride / Ethopropazine HCl / ethopropazine monohydrochloride / N,N-diethyl-α-methyl-10H-phenothiazine-10-ethylamine hydrochloride / N,N-diethyl-α-methyl-10H-phenothiazine-10-ethylamine monohydrochloride / profenamine HCl / Profenamine hydrochloride / profenamine monohydrochloride
- UNII
- O00T1I1VRN
- CAS Number
- 1094-08-2
- Weight
- Average: 348.933
Monoisotopic: 348.142697207 - Chemical Formula
- C19H25ClN2S
- InChI Key
- VXPCQISYVPFYRK-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
- IUPAC Name
- diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine hydrochloride
- SMILES
- Cl.CCN(CC)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12
- External Links
- KEGG Drug
- D01118
- PubChem Compound
- 122824
- ChemSpider
- 109488
- ChEBI
- 31568
- ChEMBL
- CHEMBL1200970
- Wikipedia
- Profenamine
- Predicted Properties
Property Value Source Water Solubility 0.00524 mg/mL ALOGPS logP 5.75 ALOGPS logP 5 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.6 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 98 m3·mol-1 Chemaxon Polarizability 36.24 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon