Omeprazole sodiumProduct ingredient for Omeprazole

Name
Omeprazole sodium
Drug Entry
Omeprazole

Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs 6. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults Label.

Accession Number
DBSALT000857
Structure
Thumb
Synonyms
Not Available
UNII
KV03YZ6QLW
CAS Number
95510-70-6
Weight
Average: 367.4
Monoisotopic: 367.09665691
Chemical Formula
C17H18N3NaO3S
InChI Key
RYXPMWYHEBGTRV-UHFFFAOYSA-N
InChI
InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1
IUPAC Name
sodium 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazol-1-ide
SMILES
[Na+].COC1=CC=C2[N-]C(=NC2=C1)[S+]([O-])CC1=NC=C(C)C(OC)=C1C
External Links
PubChem Compound
10959536
ChemSpider
51311
ChEBI
31934
ChEMBL
CHEMBL2105294
Predicted Properties
PropertyValueSource
Water Solubility0.516 mg/mLALOGPS
logP1.68ALOGPS
logP2.43ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)9.68ChemAxon
pKa (Strongest Basic)4.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area74.2 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity94.27 m3·mol-1ChemAxon
Polarizability37.16 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon