Milrinone lactateProduct ingredient for Milrinone
- Name
- Milrinone lactate
- Drug Entry
- Milrinone
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart failure is underpinned by numerous physiological changes, including alteration in β-adrenergic signalling and cyclic adenosine monophosphate (cAMP) production, which affects the heart's contractile function and cardiac output.1 Milrinone is a second-generation bipyridine phosphodiesterase (PDE) inhibitor created through chemical modification of amrinone.2 As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function and peripheral vasodilation in acute decongested heart failure.3,7,1,2,4,8
Milrinone was originally synthesized at the Sterling Winthrop Research Institute in the 1980s.2 It was approved by the FDA on December 31, 1987, and was marketed under the trademark PRIMACOR® by Sanofi-Aventis US before being discontinued.8
- Accession Number
- DBSALT000891
- Structure
Structure for Milrinone lactate (DBSALT000891)
- Synonyms
- Not Available
- UNII
- 9K8XR81MO8
- CAS Number
- 100286-97-3
- Weight
- Average: 301.302
Monoisotopic: 301.106255975 - Chemical Formula
- C15H15N3O4
- InChI Key
- VWUPWEAFIOQCGF-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8;1-2(4)3(5)6/h2-6H,1H3,(H,15,16);2,4H,1H3,(H,5,6)
- IUPAC Name
- 2-hydroxypropanoic acid; 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
- SMILES
- CC(O)C(O)=O.CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.209 mg/mL ALOGPS logP 1.04 ALOGPS logP 0.33 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 7.54 Chemaxon pKa (Strongest Basic) 4.82 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 65.78 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 61.14 m3·mol-1 Chemaxon Polarizability 21.48 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon