Disopyramide phosphateProduct ingredient for Disopyramide

Name
Disopyramide phosphate
Drug Entry
Disopyramide

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

Accession Number
DBSALT000899
Structure
Synonyms
Not Available
UNII
N6BOM1935W
CAS Number
22059-60-5
Weight
Average: 437.477
Monoisotopic: 437.20795814
Chemical Formula
C21H32N3O5P
InChI Key
CGDDQFMPGMYYQP-UHFFFAOYSA-N
InChI
InChI=1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
IUPAC Name
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide; phosphoric acid
SMILES
OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=N1)C(C)C
KEGG Compound
C07740
PubChem Compound
30928
ChemSpider
28696
ChEBI
4658
ChEMBL
CHEMBL1201020
Wikipedia
Disopyramide
Predicted Properties
PropertyValueSource
Water Solubility0.0493 mg/mLALOGPS
logP3.21ALOGPS
logP3.47Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)16.19Chemaxon
pKa (Strongest Basic)10.42Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area59.22 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity102.3 m3·mol-1Chemaxon
Polarizability38.93 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon