Tolazoline hydrochlorideProduct ingredient for Tolazoline
- Name
- Tolazoline hydrochloride
- Drug Entry
- Tolazoline
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
- Accession Number
- DBSALT000948
- Structure
Structure for Tolazoline hydrochloride (DBSALT000948)
- Synonyms
- Tolazoline HCl
- UNII
- E669Z6S1JG
- CAS Number
- 59-97-2
- Weight
- Average: 196.68
Monoisotopic: 196.0767261 - Chemical Formula
- C10H13ClN2
- InChI Key
- RHTNTTODYGNRSP-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
- IUPAC Name
- 2-benzyl-4,5-dihydro-1H-imidazole hydrochloride
- SMILES
- Cl.C(C1=NCCN1)C1=CC=CC=C1
- External Links
- ChemSpider
- 5825
- ChEBI
- 9615
- ChEMBL
- CHEMBL1689
- Wikipedia
- Tolazoline
- Predicted Properties
Property Value Source Water Solubility 1.36 mg/mL ALOGPS logP 2.05 ALOGPS logP 1.2 Chemaxon logS -2.1 ALOGPS pKa (Strongest Basic) 10.25 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 24.39 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 49.07 m3·mol-1 Chemaxon Polarizability 17.98 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon