Tolazoline hydrochlorideProduct ingredient for Tolazoline

Name
Tolazoline hydrochloride
Drug Entry
Tolazoline

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.

Accession Number
DBSALT000948
Structure
Thumb
Synonyms
Tolazoline HCl
UNII
E669Z6S1JG
CAS Number
59-97-2
Weight
Average: 196.68
Monoisotopic: 196.0767261
Chemical Formula
C10H13ClN2
InChI Key
RHTNTTODYGNRSP-UHFFFAOYSA-N
InChI
InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
IUPAC Name
2-benzyl-4,5-dihydro-1H-imidazole hydrochloride
SMILES
Cl.C(C1=NCCN1)C1=CC=CC=C1
External Links
ChemSpider
5825
ChEBI
9615
ChEMBL
CHEMBL1689
Wikipedia
Tolazoline
Predicted Properties
PropertyValueSource
Water Solubility1.36 mg/mLALOGPS
logP2.05ALOGPS
logP1.2ChemAxon
logS-2.1ALOGPS
pKa (Strongest Basic)10.25ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area24.39 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity49.07 m3·mol-1ChemAxon
Polarizability17.98 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon