Clidinium BromideProduct ingredient for Clidinium
- Name
- Clidinium Bromide
- Drug Entry
- Clidinium
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
- Accession Number
- DBSALT000958
- Structure
Structure for Clidinium Bromide (DBSALT000958)
- Synonyms
- Not Available
- External IDs
- RO 2-3773 / RO-2-3773
- UNII
- 91ZQW5JF1Z
- CAS Number
- 3485-62-9
- Weight
- Average: 432.358
Monoisotopic: 431.109607 - Chemical Formula
- C22H26BrNO3
- InChI Key
- GKEGFOKQMZHVOW-UHFFFAOYSA-M
- InChI
- InChI=1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H/q+1;/p-1
- IUPAC Name
- 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
- SMILES
- [Br-].C[N+]12CCC(CC1)C(C2)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 17942
- ChEMBL
- CHEMBL1200950
- Predicted Properties
Property Value Source Water Solubility 0.000361 mg/mL ALOGPS logP -0.65 ALOGPS logP -1.1 Chemaxon logS -6.1 ALOGPS pKa (Strongest Acidic) 11.05 Chemaxon pKa (Strongest Basic) -4.5 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 112.14 m3·mol-1 Chemaxon Polarizability 38.58 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon