Azatadine maleateProduct ingredient for Azatadine
- Name
- Azatadine maleate
- Drug Entry
- Azatadine
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
- Accession Number
- DBSALT000973
- Structure
Structure for Azatadine maleate (DBSALT000973)
- Synonyms
- Not Available
- UNII
- F3Q391WTX7
- CAS Number
- 3978-86-7
- Weight
- Average: 522.554
Monoisotopic: 522.200215934 - Chemical Formula
- C28H30N2O8
- InChI Key
- SGHXFFAHXTZRQM-SPIKMXEPSA-N
- InChI
- InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
- IUPAC Name
- bis((2Z)-but-2-enedioic acid); 2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene
- SMILES
- OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C1C2=C(CCC3=CC=CN=C13)C=CC=C2
- External Links
- ChemSpider
- 4444523
- ChEBI
- 2947
- ChEMBL
- CHEMBL3544908
- Wikipedia
- Azatadine
- Predicted Properties
Property Value Source Water Solubility 0.113 mg/mL ALOGPS logP 3.67 ALOGPS logP 3.75 Chemaxon logS -3.4 ALOGPS pKa (Strongest Basic) 7.91 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 16.13 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 101.53 m3·mol-1 Chemaxon Polarizability 34.01 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon