Procyclidine hydrochlorideProduct ingredient for Procyclidine

Name
Procyclidine hydrochloride
Drug Entry
Procyclidine

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.

Accession Number
DBSALT001008
Structure
Thumb
Synonyms
Procyclidine HCl
UNII
CQC932Z7YW
CAS Number
1508-76-5
Weight
Average: 323.91
Monoisotopic: 323.2015923
Chemical Formula
C19H30ClNO
InChI Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
InChI
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
IUPAC Name
1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol hydrochloride
SMILES
Cl.OC(CCN1CCCC1)(C1CCCCC1)C1=CC=CC=C1
External Links
ChemSpider
180115
ChEBI
8449
ChEMBL
CHEMBL1761
Wikipedia
Procyclidine
Predicted Properties
PropertyValueSource
Water Solubility0.00984 mg/mLALOGPS
logP4.13ALOGPS
logP3.79ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)13.84ChemAxon
pKa (Strongest Basic)9.45ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area23.47 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity88.6 m3·mol-1ChemAxon
Polarizability34.64 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon