Darifenacin hydrobromideProduct ingredient for Darifenacin
- Name
- Darifenacin hydrobromide
- Drug Entry
- Darifenacin
Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence.
Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention.
It is unknown if M3 receptor selectivity is clinically advantageous in overactive bladder syndrome treatments.
- Accession Number
- DBSALT001041
- Structure
Structure for Darifenacin hydrobromide (DBSALT001041)
- Synonyms
- Not Available
- UNII
- CR02EYQ8GV
- CAS Number
- 133099-07-7
- Weight
- Average: 507.472
Monoisotopic: 506.156891 - Chemical Formula
- C28H31BrN2O2
- InChI Key
- UQAVIASOPREUIT-VQIWEWKSSA-N
- InChI
- InChI=1S/C28H30N2O2.BrH/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26;/h1-12,19,25H,13-18,20H2,(H2,29,31);1H/t25-;/m1./s1
- IUPAC Name
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylethanimidic acid hydrobromide
- SMILES
- Br.[H][C@]1(CCN(CCC2=CC3=C(OCC3)C=C2)C1)C(C(O)=N)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 392053
- ChEBI
- 31455
- ChEMBL
- CHEMBL1200935
- Wikipedia
- Darifenacin
- Predicted Properties
Property Value Source Water Solubility 0.000477 mg/mL ALOGPS logP 4.71 ALOGPS logP 2.67 Chemaxon logS -6 ALOGPS pKa (Strongest Acidic) -1.8 Chemaxon pKa (Strongest Basic) 13.04 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 56.55 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 149.93 m3·mol-1 Chemaxon Polarizability 48.32 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon