Tacrine HydrochlorideProduct ingredient for Tacrine

Show full entry for Tacrine
Name
Tacrine Hydrochloride
Drug Entry
Tacrine

A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.

See full entry for Tacrine
Accession Number
DBSALT001053
Structure
Similar Structures
Synonyms
Tacrine HCl
UNII
4966RNG0BU
CAS Number
1684-40-8
Weight
Average: 234.73
Monoisotopic: 234.0923762
Chemical Formula
C13H15ClN2
InChI Key
ZUFVXZVXEJHHBN-UHFFFAOYSA-N
InChI
InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
IUPAC Name
1,2,3,4,9,10-hexahydroacridin-9-imine hydrochloride
SMILES
Cl.N=C1C2=C(CCCC2)NC2=CC=CC=C12
ChemSpider
14764
ChEMBL
CHEMBL1677
Wikipedia
Tacrine
Predicted Properties
PropertyValueSource
Water Solubility0.135 mg/mLALOGPS
logP2.39ALOGPS
logP2.41Chemaxon
logS-3.2ALOGPS
pKa (Strongest Acidic)15.91Chemaxon
pKa (Strongest Basic)12.41Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area35.88 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity74.99 m3·mol-1Chemaxon
Polarizability22.73 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon