Fluorometholone acetateProduct ingredient for Fluorometholone
- Name
- Fluorometholone acetate
- Drug Entry
- Fluorometholone
A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
- Accession Number
- DBSALT001065
- Structure
- Synonyms
- Not Available
- UNII
- 9I50C3I3OK
- CAS Number
- 3801-06-7
- Weight
- Average: 418.505
Monoisotopic: 418.215552261 - Chemical Formula
- C24H31FO5
- InChI Key
- YRFXGQHBPBMFHW-SBTZIJSASA-N
- InChI
- InChI=1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17-,19-,20-,21-,22-,23-,24-/m0/s1
- IUPAC Name
- (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-17-hydroxy-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl acetate
- SMILES
- [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@]([H])(O)[C@@]1(F)[C@@]2([H])C[C@]([H])(C)C2=CC(=O)C=C[C@]12C
- External Links
- ChemSpider
- 210390
- ChEBI
- 78354
- ChEMBL
- CHEMBL1201064
- ZINC
- ZINC000004213357
- Wikipedia
- Fluorometholone_acetate
- Predicted Properties
Property Value Source Water Solubility 0.00627 mg/mL ALOGPS logP 2.76 ALOGPS logP 2.86 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 13.64 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 80.67 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 110.02 m3·mol-1 Chemaxon Polarizability 44.16 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon