Bromhexine hydrochlorideProduct ingredient for Bromhexine

Name
Bromhexine hydrochloride
Drug Entry
Bromhexine

Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.1 Recently, bromhexine and its metabolite ambroxol have garnered interest for the potential prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs.5,6

Accession Number
DBSALT001092
Structure
Synonyms
Bromhexine HCl
UNII
YC2ZOM3Z8V
CAS Number
611-75-6
Weight
Average: 412.59
Monoisotopic: 409.976002
Chemical Formula
C14H21Br2ClN2
InChI Key
UCDKONUHZNTQPY-UHFFFAOYSA-N
InChI
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
IUPAC Name
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride
SMILES
Cl.CN(CC1=CC(Br)=CC(Br)=C1N)C1CCCCC1
ChemSpider
4642584
ChEBI
31303
ChEMBL
CHEMBL1319139
Predicted Properties
PropertyValueSource
Water Solubility0.00362 mg/mLALOGPS
logP4.08ALOGPS
logP4.42Chemaxon
logS-5ALOGPS
pKa (Strongest Acidic)19.89Chemaxon
pKa (Strongest Basic)9.03Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area29.26 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity85.56 m3·mol-1Chemaxon
Polarizability32.98 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon