Dimetacrine bitartrateProduct ingredient for Dimetacrine

Name
Dimetacrine bitartrate
Drug Entry
Dimetacrine

Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. Dimetacrine is no longer used in Japan.

Accession Number
DBSALT001096
Structure
Synonyms
Not Available
UNII
DVH164X0IF
CAS Number
3759-07-7
Weight
Average: 444.528
Monoisotopic: 444.226036758
Chemical Formula
C24H32N2O6
InChI Key
IIYKUJVECNNTEY-LREBCSMRSA-N
InChI
InChI=1S/C20H26N2.C4H6O6/c1-20(2)16-10-5-7-12-18(16)22(15-9-14-21(3)4)19-13-8-6-11-17(19)20;5-1(3(7)8)2(6)4(9)10/h5-8,10-13H,9,14-15H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
IUPAC Name
(2R,3R)-2,3-dihydroxybutanedioic acid; [3-(9,9-dimethyl-9,10-dihydroacridin-10-yl)propyl]dimethylamine
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(C)CCCN1C2=CC=CC=C2C(C)(C)C2=C1C=CC=C2
KEGG Compound
C12959
ChemSpider
85084
ChEBI
31497
Predicted Properties
PropertyValueSource
Water Solubility0.0343 mg/mLALOGPS
logP4.96ALOGPS
logP4.42Chemaxon
logS-3.9ALOGPS
pKa (Strongest Basic)9.2Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area6.48 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity105.52 m3·mol-1Chemaxon
Polarizability35.6 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon