Hexaminolevulinate hydrochlorideProduct ingredient for Hexaminolevulinate

Name
Hexaminolevulinate hydrochloride
Drug Entry
Hexaminolevulinate

Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for Intravesical Solution, Photocure ASA), as an optical imaging agent for use in combination with the Karl Storz Photodynamic Diagnostic D-Light C (PDD) System for cystoscopic detection of non-muscle invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis of a prior cystoscopy. Hexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. In Europe, Hexaminolevulinate is marketed under the brand Hexvix®.

Accession Number
DBSALT001174
Structure
Thumb
Synonyms
Hexaminolevulinate HCl
UNII
D4F329SL1O
CAS Number
140898-91-5
Weight
Average: 251.75
Monoisotopic: 251.1288213
Chemical Formula
C11H22ClNO3
InChI Key
LZYXPFZBAZTOCH-UHFFFAOYSA-N
InChI
InChI=1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
IUPAC Name
hexyl 5-amino-4-oxopentanoate hydrochloride
SMILES
Cl.CCCCCCOC(=O)CCC(=O)CN
External Links
ChemSpider
4938271
ChEMBL
CHEMBL1201785
Predicted Properties
PropertyValueSource
Water Solubility0.511 mg/mLALOGPS
logP1.55ALOGPS
logP1.37ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)16.11ChemAxon
pKa (Strongest Basic)7.83ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area69.39 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity58.29 m3·mol-1ChemAxon
Polarizability25.04 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon