Pramipexole dihydrochloride monohydrateProduct ingredient for Pramipexole

Name
Pramipexole dihydrochloride monohydrate
Drug Entry
Pramipexole

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) 6. It was first approved by the FDA in 1997 12. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients 2, leading to increased difficulty in performing activities of daily living due to symptoms that progress over time 3. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 4. This increase may be attributed to an aging population along with other contributing factors 4.

In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS) 8. RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs 9.

Accession Number
DBSALT001198
Structure
Synonyms
pramipexole dihydrochloride
UNII
3D867NP06J
CAS Number
191217-81-9
Weight
Average: 302.26
Monoisotopic: 301.0782389
Chemical Formula
C10H21Cl2N3OS
InChI Key
APVQOOKHDZVJEX-QTPLPEIMSA-N
InChI
InChI=1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1
IUPAC Name
(6S)-2-imino-N-propyl-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-6-amine hydrate dihydrochloride
SMILES
O.Cl.Cl.[H][C@@]1(CCC2=C(C1)SC(=N)N2)NCCC
ChemSpider
145780
ChEBI
51147
ChEMBL
CHEMBL3182733
Wikipedia
Pramipexole
Predicted Properties
PropertyValueSource
Water Solubility0.746 mg/mLALOGPS
logP1.42ALOGPS
logP1.02Chemaxon
logS-2.4ALOGPS
pKa (Strongest Acidic)11Chemaxon
pKa (Strongest Basic)9.83Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area47.91 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity73.52 m3·mol-1Chemaxon
Polarizability24.35 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon