Clodronate disodiumProduct ingredient for Clodronic acid
- Name
- Clodronate disodium
- Drug Entry
- Clodronic acid
Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid.1 These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.2 clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.1
Clodronic acid is not FDA approved, but is approved in Canada.8
- Accession Number
- DBSALT000972 (DBSALT001199)
- Structure
Structure for Clodronate disodium (DBSALT000972)
- Synonyms
- Clodronate disodium tetrahydrate / Disodium clodronate tetrahydrate
- UNII
- N030400H8J
- CAS Number
- 88416-50-6
- Weight
- Average: 360.91
Monoisotopic: 359.8921645 - Chemical Formula
- CH10Cl2Na2O10P2
- InChI Key
- XWHPUCFOTRBMGS-UHFFFAOYSA-L
- InChI
- InChI=1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
- IUPAC Name
- disodium tetrahydrate hydrogen [dichloro(hydrogen phosphono)methyl]phosphonate
- SMILES
- O.O.O.O.[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
- External Links
- ChemSpider
- 21332554
- ChEBI
- 59587
- Wikipedia
- Clodronic_acid
- Predicted Properties
Property Value Source Water Solubility 20.8 mg/mL ALOGPS logP 0.81 ALOGPS logP -0.067 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 0.62 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 120.72 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 35.97 m3·mol-1 Chemaxon Polarizability 14.39 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon