Ceftriaxone sodiumProduct ingredient for Ceftriaxone
- Name
- Ceftriaxone sodium
- Drug Entry
- Ceftriaxone
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.1 It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges1, eyes9, and inner ear6. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.1
- Accession Number
- DBSALT001213
- Structure
Structure for Ceftriaxone sodium (DBSALT001213)
- Synonyms
- Ceftriaxone disodium hemiheptahydrate / Ceftriaxone sodium
- External IDs
- Ro 13-9904
- UNII
- 023Z5BR09K
- CAS Number
- 104376-79-6
- Weight
- Average: 1323.17
Monoisotopic: 1322.09384673 - Chemical Formula
- C36H46N16Na4O21S6
- InChI Key
- PMRZKYOXTPBIQF-MAODNAKNSA-J
- InChI
- InChI=1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H5,19,20,21,23,27,29,31,32);;;;;7*1H2/q;;4*+1;;;;;;;/p-4/b2*24-8-;;;;;;;;;;;/t2*9-,15-;;;;;;;;;;;/m11.........../s1
- IUPAC Name
- tetrasodium bis(3-({[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}sulfanyl)-2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-1-ide) heptahydrate
- SMILES
- O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(CSC3=NC(=O)C(=O)[N-]N3C)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1.CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(CSC3=NC(=O)C(=O)[N-]N3C)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1
- External Links
- ChemSpider
- 10128196
- ChEBI
- 3514
- Wikipedia
- Ceftriaxone
- Predicted Properties
Property Value Source Water Solubility 0.123 mg/mL ALOGPS logP 0.52 ALOGPS logP -2.4 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 3.05 Chemaxon pKa (Strongest Basic) 4.29 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 13 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 209.01 Å2 Chemaxon Rotatable Bond Count 16 Chemaxon Refractivity 138.5 m3·mol-1 Chemaxon Polarizability 49.64 Å3 Chemaxon Number of Rings 8 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon