Tetrahydrozoline hydrochlorideProduct ingredient for Tetryzoline
- Name
- Tetrahydrozoline hydrochloride
- Drug Entry
- Tetryzoline
Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties.4 Available since the 1950s, tetryzoline is a selective α1-receptor agonist 5 that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, Visine.9 Tetryzoline is also found in combination products with other lubricants and anti-irritants, such as povidone, polyethylene glycol 400, dextran, and zinc sulfate.10,11,12 It is also used in combination with other drug classes, such as antihistamines, corticosteroids, and glucocorticoids in other countries. Tetryzoline is also found in nasal spray under the trade name Tyzine, which is used for decongestion of nasal and nasopharyngeal mucosa.13
As it causes profound sedation in children and adults, tetryzoline is increasingly becoming scrutinized for possible drug overdose and toxicity from accidental ingestion.2,4 It has also been misused for non-therapeutic purposes as a causative drug for several cases of drug-facilitated sexual assault.3
- Accession Number
- DBSALT001254
- Structure
Structure for Tetrahydrozoline hydrochloride (DBSALT001254)
- Synonyms
- Tetrahydrozoline HCl
- UNII
- 0YZT43HS7D
- CAS Number
- 522-48-5
- Weight
- Average: 236.74
Monoisotopic: 236.1080263 - Chemical Formula
- C13H17ClN2
- InChI Key
- BJORNXNYWNIWEY-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
- IUPAC Name
- 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole hydrochloride
- SMILES
- Cl.C1CN=C(N1)C1CCCC2=CC=CC=C12
- External Links
- ChemSpider
- 10200
- ChEBI
- 9492
- ChEMBL
- CHEMBL1200413
- Wikipedia
- Tetryzoline
- Predicted Properties
Property Value Source Water Solubility 0.239 mg/mL ALOGPS logP 3.11 ALOGPS logP 2.24 Chemaxon logS -2.9 ALOGPS pKa (Strongest Basic) 10.17 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 24.39 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 61.48 m3·mol-1 Chemaxon Polarizability 23.01 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon