Bazedoxifene acetateProduct ingredient for Bazedoxifene
- Name
- Bazedoxifene acetate
- Drug Entry
- Bazedoxifene
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the European Union (marketed in Italy and Spain) and Japan as monotherapy. In 2013, the combination product containing conjugated estrogens and bazedoxifene was approved by the FDA for the treatment of moderate to severe vasomotor symptoms associated with menopause, as well as the prevention of postmenopausal osteoporosis in women.
- Accession Number
- DBSALT001296
- Structure
- Synonyms
- Not Available
- UNII
- J70472UD3D
- CAS Number
- 198481-33-3
- Weight
- Average: 530.665
Monoisotopic: 530.278072332 - Chemical Formula
- C32H38N2O5
- InChI Key
- OMZAMQFQZMUNTP-UHFFFAOYSA-N
- InChI
- InChI=1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)
- IUPAC Name
- 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol; acetic acid
- SMILES
- CC(O)=O.CC1=C(N(CC2=CC=C(OCCN3CCCCCC3)C=C2)C2=C1C=C(O)C=C2)C1=CC=C(O)C=C1
- External Links
- ChemSpider
- 135920
- ChEMBL
- CHEMBL2106615
- Wikipedia
- Bazedoxifene
- Predicted Properties
Property Value Source Water Solubility 0.000564 mg/mL ALOGPS logP 6.03 ALOGPS logP 6.01 Chemaxon logS -5.9 ALOGPS pKa (Strongest Acidic) 9.63 Chemaxon pKa (Strongest Basic) 9.09 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 57.86 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 141.9 m3·mol-1 Chemaxon Polarizability 54.06 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon