Amphetamine adipateProduct ingredient for Amphetamine

Name
Amphetamine adipate
Drug Entry
Amphetamine

Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. By mimicking the structures of the catecholamine neurotransmitters, noradrenaline and dopamine, amphetamines modulate monoamine release, reuptake, and signalling within the brain. Although "amphetamine" is used as a descriptor of its own structural class, amphetamine properly refers to a racemic free base composed of equal parts of its two optical antipodes: levo-amphetamine and dextro-amphetamine. Used in the past for the treatment of depression, stress, and for concentration improvement, it is currently available as a prescription drug for the treatment of attention hyperactivity disorder (ADHD), narcolepsy, and as an adjunct in the treatment of exogenous obesity. Amphetamine is also available in a mixed salt/mixed enantiomer form (Adderall), where d-amphetamine and l-amphetamine are available in a ratio of 3:1. It is also available in a prodrug form as lisdexamfetamine.

Accession Number
DBSALT001323
Structure
Thumb
Synonyms
Amfetamine adipate
UNII
Z58RH02W4M
CAS Number
64770-51-0
Weight
Average: 281.352
Monoisotopic: 281.162708225
Chemical Formula
C15H23NO4
InChI Key
OFCJKOOVFDGTLY-UHFFFAOYSA-N
InChI
InChI=1S/C9H13N.C6H10O4/c1-8(10)7-9-5-3-2-4-6-9;7-5(8)3-1-2-4-6(9)10/h2-6,8H,7,10H2,1H3;1-4H2,(H,7,8)(H,9,10)
IUPAC Name
1-phenylpropan-2-amine; hexanedioic acid
SMILES
CC(N)CC1=CC=CC=C1.OC(=O)CCCCC(O)=O
External Links
ChemSpider
15186703
ChEMBL
CHEMBL1200387
Wikipedia
Amphetamine
Predicted Properties
PropertyValueSource
Water Solubility32.2 mg/mLALOGPS
logP0.13ALOGPS
logP1.8ChemAxon
logS-0.66ALOGPS
pKa (Strongest Basic)10.01ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.02 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity43.71 m3·mol-1ChemAxon
Polarizability16.18 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon