Levopropoxyphene napsylate anhydrousProduct ingredient for Levopropoxyphene
- Name
- Levopropoxyphene napsylate anhydrous
- Drug Entry
- Levopropoxyphene
Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s.3 Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. This drug presented different dosages and it was administered as a capsule or suspension.
- Accession Number
- DBSALT001392
- Structure
- Synonyms
- Levopropoxyphene 2-naphthalenesulfonate / Levopropoxyphene napsilate anhydrous / Levopropoxyphene napsylate, anhydrous
- UNII
- W7DQT6KY5S
- CAS Number
- 5714-90-9
- Weight
- Average: 547.71
Monoisotopic: 547.239244469 - Chemical Formula
- C32H37NO5S
- InChI Key
- VZPXFHVJUUSVLH-VNJAQMQMSA-N
- InChI
- InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m0./s1
- IUPAC Name
- (2R,3S)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate; naphthalene-2-sulfonic acid
- SMILES
- OS(=O)(=O)C1=CC=C2C=CC=CC2=C1.CCC(=O)O[C@](CC1=CC=CC=C1)([C@@H](C)CN(C)C)C1=CC=CC=C1
- External Links
- ChemSpider
- 5036775
- ChEMBL
- CHEMBL1593906
- Predicted Properties
Property Value Source Water Solubility 0.00419 mg/mL ALOGPS logP 4.06 ALOGPS logP 4.9 Chemaxon logS -4.9 ALOGPS pKa (Strongest Basic) 9.52 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 29.54 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 102.88 m3·mol-1 Chemaxon Polarizability 39.02 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon