Tazobactam sodiumProduct ingredient for Tazobactam
- Name
- Tazobactam sodium
- Drug Entry
- Tazobactam
Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a variety of bacterial infections.
Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved by the FDA in 2014Label, providing wider antibacterial coverage for gram-negative infections. In June 2019, ceftolozane-tazobactam was approved by the FDA for treating hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia, which are significant causes of morbidity and mortality in hospitalized patients.15
- Accession Number
- DBSALT001475
- Structure
Structure for Tazobactam sodium (DBSALT001475)
- Synonyms
- Not Available
- UNII
- UXA545ABTT
- CAS Number
- 89785-84-2
- Weight
- Average: 322.27
Monoisotopic: 322.03478492 - Chemical Formula
- C10H11N4NaO5S
- InChI Key
- RFMIKMMOLPNEDG-QVUDESDKSA-M
- InChI
- InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1
- IUPAC Name
- sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- SMILES
- [Na+].[H][C@@]12CC(=O)N1[C@@]([H])(C([O-])=O)[C@](C)(CN1C=CN=N1)S2(=O)=O
- External Links
- ChemSpider
- 5293097
- BindingDB
- 50157692
- ChEBI
- 85192
- ChEMBL
- CHEMBL1439
- Wikipedia
- Tazobactam
- Predicted Properties
Property Value Source Water Solubility 10.3 mg/mL ALOGPS logP -0.87 ALOGPS logP -1.4 Chemaxon logS -1.5 ALOGPS pKa (Strongest Acidic) 2.86 Chemaxon pKa (Strongest Basic) 0.75 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 125.29 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 85.65 m3·mol-1 Chemaxon Polarizability 25.75 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon