Bicisate dihydrochlorideProduct ingredient for Bicisate
- Name
- Bicisate dihydrochloride
- Drug Entry
- Bicisate
Bicisate, also known as ethyl cysteinate dimer (ECD), is a N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is used in conjunction with technetium Tc99m as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT).1 The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved on November 23, 1994.8
- Accession Number
- DBSALT001533
- Structure
Structure for Bicisate dihydrochloride (DBSALT001533)
- Synonyms
- Bicisate diHCl
- UNII
- B005P07V07
- CAS Number
- 14344-58-2
- Weight
- Average: 397.37
Monoisotopic: 396.0711051 - Chemical Formula
- C12H26Cl2N2O4S2
- InChI Key
- HKASNZKRIQURIX-BZDVOYDHSA-N
- InChI
- InChI=1S/C12H24N2O4S2.2ClH/c1-3-17-11(15)9(7-19)13-5-6-14-10(8-20)12(16)18-4-2;;/h9-10,13-14,19-20H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
- IUPAC Name
- ethyl (2R)-2-[(2-{[(2R)-1-ethoxy-1-oxo-3-sulfanylpropan-2-yl]amino}ethyl)amino]-3-sulfanylpropanoate dihydrochloride
- SMILES
- Cl.Cl.[H][C@@](CS)(NCCN[C@@]([H])(CS)C(=O)OCC)C(=O)OCC
- External Links
- ChemSpider
- 29738657
- Predicted Properties
Property Value Source Water Solubility 0.0867 mg/mL ALOGPS logP 1.28 ALOGPS logP 0.64 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 9.65 Chemaxon pKa (Strongest Basic) 5.76 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 76.66 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 83.06 m3·mol-1 Chemaxon Polarizability 34.14 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon