Homatropine hydrobromideProduct ingredient for Homatropine
- Name
- Homatropine hydrobromide
- Drug Entry
- Homatropine
Homatropine is an anticholinergic drug that acts as an antagonist at muscarinic acetylcholine receptors. It is present in antitussives, under the trade name Hycodan, in combination with hydrocodone (dihydrocodeinone) bitartrate indicated for the symptomatic relief of cough as oral tablets or solutions. Homatropine is included in subtherapeutic amounts as homatropine methylbromide to discourage deliberate overdosage. Homatropine hydrobromide has been administered as ophthalmic solutions as a cycloplegic to temporarily paralyze accomodation, and to induce mydriasis (the dilation of the pupil); however such therapeutic use has not been approved by the FDA to be safe and effective.
- Accession Number
- DBSALT001537
- Structure
Structure for Homatropine hydrobromide (DBSALT001537)
- Synonyms
- Not Available
- UNII
- BEW7469QZ0
- CAS Number
- 51-56-9
- Weight
- Average: 356.26
Monoisotopic: 355.078307 - Chemical Formula
- C16H22BrNO3
- InChI Key
- DWSGTFTVBLXELC-RDYJJYPNSA-N
- InChI
- InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
- IUPAC Name
- (1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate hydrobromide
- SMILES
- Br.[H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(O)C1=CC=CC=C1)N2C
- External Links
- ChemSpider
- 16739956
- ChEMBL
- CHEMBL1319362
- Wikipedia
- Homatropine
- Predicted Properties
Property Value Source Water Solubility 5.57 mg/mL ALOGPS logP 1.91 ALOGPS logP 1.59 Chemaxon logS -1.7 ALOGPS pKa (Strongest Acidic) 11.99 Chemaxon pKa (Strongest Basic) 9.38 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 49.77 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 75.81 m3·mol-1 Chemaxon Polarizability 29.79 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon