Xylometazoline hydrochlorideProduct ingredient for Xylometazoline
- Name
- Xylometazoline hydrochloride
- Drug Entry
- Xylometazoline
Xylometazoline is an imidazoline derivative 4 with sympathomimetic and nasal decongestant activity. Xylometazoline works by binding to alpha (α)-adrenergic receptors to cause vasoconstriction of nasal blood vessels.2
Xylometazoline is available in over-the-counter (OTC) nasal sprays or drops to temporarily relieve nasal congestion due to cold, hay fever or other respiratory allergies. In some countries, it is available as combination products with ipratropium, domiphen, or dexpanthenol.
- Accession Number
- DBSALT001557
- Structure
Structure for Xylometazoline hydrochloride (DBSALT001557)
- Synonyms
- Xylometazoline HCl
- UNII
- X5S84033NZ
- CAS Number
- 1218-35-5
- Weight
- Average: 280.84
Monoisotopic: 280.1706265 - Chemical Formula
- C16H25ClN2
- InChI Key
- YGWFCQYETHJKNX-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
- IUPAC Name
- 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole hydrochloride
- SMILES
- Cl.CC1=CC(=CC(C)=C1CC1=NCCN1)C(C)(C)C
- External Links
- ChemSpider
- 13968
- ChEMBL
- CHEMBL1256400
- Predicted Properties
Property Value Source Water Solubility 0.00893 mg/mL ALOGPS logP 4.68 ALOGPS logP 3.78 Chemaxon logS -4.4 ALOGPS pKa (Strongest Basic) 10.29 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 24.39 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 77.82 m3·mol-1 Chemaxon Polarizability 29.85 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon