Zinc pidolateProduct ingredient for Pidolic acid

Name
Zinc pidolate
Drug Entry
Pidolic acid

Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways 4,7. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism 7. Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin 7.

There are currently little to no medicines available that are clinically approved or marketed for employing pidolic acid as an active ingredient for any particular formal indication. Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for the proposed purpose of facilitating cognitive or memory enhancement, most available research suggest exercising caution in their recommendation as much more research is necessary 1,2.

Accession Number
DBSALT001565
Structure
Synonyms
Not Available
UNII
C32PQ86DH4
CAS Number
15454-75-8
Weight
Average: 321.59
Monoisotopic: 319.998678
Chemical Formula
C10H12N2O6Zn
InChI Key
OWVLYQRCCIEOPF-QHTZZOMLSA-L
InChI
InChI=1S/2C5H7NO3.Zn/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1
IUPAC Name
zinc(2+) ion bis((2S)-5-oxopyrrolidine-2-carboxylate)
SMILES
[Zn++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1
ChemSpider
9776970
Predicted Properties
PropertyValueSource
Water Solubility32.1 mg/mLALOGPS
logP-0.66ALOGPS
logP-0.89Chemaxon
logS-1ALOGPS
pKa (Strongest Acidic)3.61Chemaxon
pKa (Strongest Basic)-2.2Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area69.23 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity38.92 m3·mol-1Chemaxon
Polarizability11.16 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon