Xylazine hydrochlorideProduct ingredient for Xylazine
- Name
- Xylazine hydrochloride
- Drug Entry
- Xylazine
Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.3,7,6 It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine.5 Xylazine is not approved for human use and requires a veterinary licence for its purchase and use.8 The intentional and unintentional use of xylazine is a cause for concern due to its side effects.4 The use of xylazine can lead to hypotension and bradycardia1,2, and when combined with central nervous system depressants, such as benzodiazepines or alcohol, it can significantly depress vital functions and increase the risk of overdose and death.7 Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs; however, it has no antidote, and the use of naloxone has no effect on xylazine.7,8
- Accession Number
- DBSALT001664
- Structure
Structure for Xylazine hydrochloride (DBSALT001664)
- Synonyms
- Xylazine HCl
- UNII
- NGC3S0882S
- CAS Number
- 23076-35-9
- Weight
- Average: 256.79
Monoisotopic: 256.0800974 - Chemical Formula
- C12H17ClN2S
- InChI Key
- QYEFBJRXKKSABU-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
- IUPAC Name
- N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine hydrochloride
- SMILES
- Cl.CC1=CC=CC(C)=C1NC1=NCCCS1
- External Links
- ChemSpider
- 61828
- ChEMBL
- CHEMBL1256022
- Predicted Properties
Property Value Source Water Solubility 0.261 mg/mL ALOGPS logP 3.23 ALOGPS logP 3.63 Chemaxon logS -2.9 ALOGPS pKa (Strongest Basic) 6.94 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 24.39 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 68.82 m3·mol-1 Chemaxon Polarizability 24.76 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon