Pipradrol hydrochlorideProduct ingredient for Pipradrol
- Name
- Pipradrol hydrochloride
- Drug Entry
- Pipradrol
Pipradrol (Meratran) 11 was initially developed in the 1950s as an antidepressant, however, the adverse effects associated with its use and its abuse potential led to its withdrawal and international regulation 12. Pipradrol was made illegal in many countries in 1970s because of its potential for abuse. It is currently classified under the Misuse of Drugs Act as a Class C substance 10.
Experimentation with the drug and its derivatives for recreational purposes has led to many cases of acute toxicity and has been linked to three fatalities. The social and in particular acute clinical harms of pipradrol derivatives have led to their control under the Misuse of Drugs Act 1971 in the UK in 2012 3.
Interestingly, this drug has been studied for bactericidal properties, however, is not currently, used for this purpose 2. In addition to this, it has shown favorable effects in postpartum depressive symptoms 6.
- Accession Number
- DBSALT001777
- Structure
Structure for Pipradrol hydrochloride (DBSALT001777)
- Synonyms
- Pipradrol HCl
- UNII
- F6E46VR9Y2
- CAS Number
- 71-78-3
- Weight
- Average: 303.83
Monoisotopic: 303.138992 - Chemical Formula
- C18H22ClNO
- InChI Key
- KIFIYUHFHGSNHL-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H21NO.ClH/c20-18(15-9-3-1-4-10-15,16-11-5-2-6-12-16)17-13-7-8-14-19-17;/h1-6,9-12,17,19-20H,7-8,13-14H2;1H
- IUPAC Name
- diphenyl(piperidin-2-yl)methanol hydrochloride
- SMILES
- Cl.OC(C1CCCCN1)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- KEGG Drug
- D01876
- ChemSpider
- 59400
- ChEBI
- 32009
- ChEMBL
- CHEMBL2106720
- Predicted Properties
Property Value Source Water Solubility 0.0306 mg/mL ALOGPS logP 3.36 ALOGPS logP 3.32 Chemaxon logS -3.9 ALOGPS pKa (Strongest Acidic) 12.88 Chemaxon pKa (Strongest Basic) 9.53 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 32.26 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 81.78 m3·mol-1 Chemaxon Polarizability 30.64 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon