Pinacidil monohydrateProduct ingredient for Pinacidil
- Name
- Pinacidil monohydrate
- Drug Entry
- Pinacidil
Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood pressure. This drug has been discontinued by the FDA.
- Accession Number
- DBSALT001806
- Structure
Structure for Pinacidil monohydrate (DBSALT001806)
- Synonyms
- Pinacidil
- UNII
- 7B0ZZH8P2W
- CAS Number
- 85371-64-8
- Weight
- Average: 263.345
Monoisotopic: 263.174610316 - Chemical Formula
- C13H21N5O
- InChI Key
- AFJCNBBHEVLGCZ-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
- IUPAC Name
- (Z)-N'-cyano-N-(3,3-dimethylbutan-2-yl)-N''-(pyridin-4-yl)guanidine hydrate
- SMILES
- O.CC(N\C(NC#N)=N\C1=CC=NC=C1)C(C)(C)C
- External Links
- KEGG Compound
- C13729
- ChemSpider
- 49968
- ChEBI
- 34923
- ChEMBL
- CHEMBL1200338
- Predicted Properties
Property Value Source Water Solubility 0.136 mg/mL ALOGPS logP 2.3 ALOGPS logP 1.94 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 16.28 Chemaxon pKa (Strongest Basic) 8.16 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 73.1 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 73.04 m3·mol-1 Chemaxon Polarizability 27.31 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon