Carbidopa hydrateProduct ingredient for Carbidopa
- Name
- Carbidopa hydrate
- Drug Entry
- Carbidopa
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with levodopa. An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy levodopa/carbidopa is not efficient reducing nausea.9
The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014.10 On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination therapy developed by Mayne Pharma in 1992.11
- Accession Number
- DBSALT001834
- Structure
Structure for Carbidopa hydrate (DBSALT001834)
- Synonyms
- (−)-L-α-hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate / (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate / (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate / (S)-(−)-carbidopa hydrate / (S)-carbidopa hydrate / (αS)-α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate / Carbidopa monohydrate / Carbidopum monohydricum / L-α-(3,4-dihydroxybenzyl)-α-hydrazinopropionic acid monohydrate
- UNII
- MNX7R8C5VO
- CAS Number
- 38821-49-7
- Weight
- Average: 244.2444
Monoisotopic: 244.105921632 - Chemical Formula
- C10H16N2O5
- InChI Key
- QTAOMKOIBXZKND-PPHPATTJSA-N
- InChI
- InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
- IUPAC Name
- (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
- SMILES
- O.C[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=O
- External Links
- Human Metabolome Database
- HMDB0014336
- KEGG Drug
- D00558
- ChemSpider
- 34931
- ChEBI
- 3395
- ChEMBL
- CHEMBL1200748
- Predicted Properties
Property Value Source Water Solubility 3.73 mg/mL ALOGPS logP -0.16 ALOGPS logP -1.2 Chemaxon logS -1.8 ALOGPS pKa (Strongest Acidic) 2.35 Chemaxon pKa (Strongest Basic) 5.66 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 115.81 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 68.77 m3·mol-1 Chemaxon Polarizability 21.81 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon